Autoerythrocyte Sensitization (Painful Bruising) Syndrome

An Extremely Rare Cause of Bruising in Children: Autoerythrocyte Sensitization Syndrome

Autoerythrocyte sensitization syndrome (ASS)—also known as Gardner-Diamond syndrome—is an autoimmune vasculopathy associated with sensitization to phosphatidylserine, a phosphoglyceride of red blood cell membranes [1]. The syndrome was first described in 1955 by Gardner and Diamond in 4 female patients [2]. ASS is typically seen in adult females; however, pediatric and male patients have also b...

Autoerythrocyte Sensitization Syndrome Treated with Kallikrein Inhibitor

I read the letter related to autoerythrocyte sensitization syndrome in a 7-year-old boy published in the Turkish Journal of Hematology [1]. I would like to remark on a few points that were not mentioned in that study. Autoerythrocyte sensitization syndrome was first described in 1972 by Karaca et al. from Turkey. They reported in detail on all characteristics in 2 patients, 19-and 23-year-old w...

Autoerythrocyte sensitization syndrome presenting with general neurodermatitis

Autoerythrocyte sensitization syndrome (AES) was first described by Gardner and Diamond in 1955, when four women with painful bruising were depicted. Patients with AES typically present with the development of recurrent, spontaneous, painful ecchymosis, frequently preceded by a prodrome of pain or itching of the skin. The patients are sensitive to their own red blood cells injected intradermall...

Painful bruising syndrome: A case report

Painful bruising syndrome (PBS) is also known as Gardner-Diamond syndrome, auto erythrocyte sensitization syndrome or psychogenic purpura. It is a rare autoimmune vasculopathy characterized by painful ecchymotic lesions which mostly recur after emotional stress [1,2]. This syndrome is frequently observed in young women with psychiatric disorders [2]. PBS occurring in a psychiatrically normal pe...

Studies in the pathogenesis of autoerythrocyte sensitization syndrome.